Differin Gel contains an Rx-strength acne-fighting retinoid. It clears breakouts where they start (deep in the pores), prevents acne before it begins, and as a result, restores skin's texture and tone. Clear and prevent acne with an Rx-strength retinoid. Fights the main causes of acne by regulating skin cell turnover & reducing inflammation deep in the skin to clear and prevent pimples, blackheads and clogged pores. Differin Gel can reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998,